Link: http://www.ncbi.nlm.nih.gov/pubmed/27342009
J Pediatr Surg. 2016 Jun;51(6):900-2. doi: 10.1016/j.jpedsurg.2016.02.049. Epub 2016 Mar 3.
Right- versus left-sided congenital diaphragmatic hernia: a comparative outcomes analysis.
Partridge EA1, Peranteau WH1, Herkert L1, Rendon N1, Smith H1, Rintoul NE1, Flake AW1, Adzick NS1, Hedrick HL2.
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Abstract
PURPOSE:
Right-sided congenital diaphragmatic hernia (R-CDH) occurs in up to 25% of all CDH cases, but has been less widely studied compared to left-sided defects. We sought to compare characteristics and outcomes of left- versus right-sided defects in a large cohort of CDH patients who underwent standardized treatment and follow-up at a single institution.
METHODS:
We retrospectively reviewed charts of all CDH patients in our pulmonary hypoplasia program from January 2002 through December 2014. Categorical variables were analyzed by Fisher's exact test and continuous variables by Mann-Whitney t-test (p≤0.05).
RESULTS:
A total of 330 CDH patients were treated more than the 12-year study period, with 274 (83%) left-sided and 56 (17%) right-sided cases identified. Specific pulmonary morbidities were associated with R-CDH, with increased duration of nitric oxide therapy, increased requirement for tracheostomy, increased requirement for supplemental oxygen at the time of NICU discharge, and increased chronic pulmonary hypertension with requirement for long-term Sildenafil therapy.
CONCLUSIONS:
In this series, R-CDH was not associated with increased mortality, but was associated with increased requirement for pulmonary vasodilatory therapy and requirement for tracheostomy. The high incidence of pulmonary complications indicates increased severity of pulmonary hypoplasia in R-CDH, supporting a role for delivery in tertiary centers with expertise in CDH management.
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