Link: https://www.ncbi.nlm.nih.gov/pubmed/31335403

Anesth Analg. 2019 Jul 17. doi: 10.1213/ANE.0000000000004324. [Epub ahead of print]

Chatterjee D1, Ing RJ1, Gien J2.
Author information
1
From the Departments of Anesthesiology.
2
Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
Abstract
Congenital diaphragmatic hernia (CDH) is a rare developmental defect of the diaphragm, characterized by herniation of abdominal contents into the chest that results in varying degrees of pulmonary hypoplasia and pulmonary hypertension (PH). Significant advances in the prenatal diagnosis and identification of prognostic factors have resulted in the continued refinement of the approach to fetal therapies for CDH. Postnatally, protocolized approaches to lung-protective ventilation, nutrition, prevention of infection, and early aggressive management of PH have led to improved outcomes in infants with CDH. Advances in our understanding of the associated left ventricular (LV) hypoplasia and myocardial dysfunction in infants with severe CDH have allowed for the optimization of hemodynamics and management of PH. This article provides a comprehensive review of CDH for the anesthesiologist, focusing on the complex pathophysiology, advances in prenatal diagnosis, fetal interventions, and optimal postnatal management of CDH.

PMID: 31335403 DOI: 10.1213/ANE.0000000000004324
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