Link: https://www.ncbi.nlm.nih.gov/pubmed/31475664

Cardiol Young. 2019 Sep 2:1-3. doi: 10.1017/S1047951119002026. [Epub ahead of print]
The use of alteplase in a newborn with an aortic arch thrombus during extracorporeal membrane oxygenation.
Yang L1, Ye L1, Lin R1.
Author information
1
Department of Extracorporeal Circulation and Extracorporeal Life Support, Heart Institute, Zhejiang University School of Medicine Children's Hospital, Hangzhou, China.
Abstract
We report a neonatal case of the use of alteplase for the lysis of a large aortic arch thrombus formed during extracorporeal membrane oxygenation support. Alteplase (0.1-0.15 mg/kg/hour) was infused for thrombolysis, and meanwhile, unfractionated heparin was administrated at 5-10 U/kg/hour for the anticoagulation purpose. Alteplase was successfully administered to this neonate after the repair of congenital diaphragmatic hernia on extracorporeal membrane oxygenation, and the patient survived without apparent catastrophic long-term complications. It is reasonable to consider alteplase therapy during extracorporeal membrane oxygenation support in this setting.

KEYWORDS:
Alteplase; extracorporeal membrane oxygenation; neonatal; thrombus

PMID: 31475664 DOI: 10.1017/S1047951119002026