Link: http://www.ncbi.nlm.nih.gov/pubmed/25746695

J Pediatr Surg. 2015 Mar;50(3):394-8. doi: 10.1016/j.jpedsurg.2014.05.039. Epub 2014 Jul 28.
Neurodevelopmental outcome in congenital diaphragmatic hernia survivors: role of ventilatory time.
Bevilacqua F1, Morini F2, Zaccara A3, Valfrč L2, Capolupo I2, Bagolan P2, Aite L4.
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Abstract
BACKGROUND:
Neurodevelopmental impairment is one of the most significant morbidities among CDH survivors.

PURPOSE:
Assess correlation between ventilatory time (VT) and short-term neurodevelopmental outcome in congenital diaphragmatic hernia (CDH) survivors.

METHODS:
A prospective longitudinal study was conducted between 2008 and 2012. Assessment of mental and motor development was performed at 6 and 12months by Bayley Scales of Infant and Toddler Development - 3rd Edition (BSID-III). ROC curve analysis was used.

RESULTS:

Forty-two subjects were included in the study. There was a significant inverse correlation between neurodevelopment at 6 and 12
months and VT during first admission (p<0.0001). VT predicting the risk of moderate (BSID-III <85) and severe (BSID-III <70) delay was 13 and 28 days, respectively (area under the curve - delay <85: 6 months mental 0.943 and motor 0.992; 12 months mental 0.877 and motor 0.925; delay <70: 6 months mental 0.934 and motor 0.943; 12 months mental 0.906 and motor 0.975; p<0.0001).

CONCLUSIONS:
VT should be considered an important marker to identify subjects at risk for short-term neurodevelopmental delay in CDH survivors. Early follow-up intervention therapy should be activated in every baby with a history exceeding 13days of VT.

Copyright © 2015 Elsevier Inc. All rights reserved.

KEYWORDS:
Congenital diaphragmatic hernia; Neurodevelopmental outcome; Ventilatory strategy
PMID: 25746695 [PubMed - in process]