Short-Term Outcomes and Medical and Surgical Interventions in Infants with CDH
Link: http://www.ncbi.nlm.nih.gov/pubmed/25825963
Am J Perinatol. 2015 Mar 31. [Epub ahead of print]
Short-Term Outcomes and Medical and Surgical Interventions in Infants with Congenital Diaphragmatic Hernia.
Grover TR1, Murthy K2, Brozanski B3, Gien J1, Rintoul N4, Keene S5, Najaf T6, Chicoine L7, Porta N2, Zaniletti I8, Pallotto EK9; and the Children's Hospitals Neonatal Consortium.
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Abstract
Objective The aim of this study is to characterize medical and surgical therapies and short-term outcomes in infants with congenital diaphragmatic hernia (CDH). Study Design Retrospective analysis of CDH infants admitted to 27 children's hospitals submitting data to Children's Hospital Neonatal Database (CHND) from 2010 to 2013, stratified by gestational age, birth weight, and survival. Results A total of 572 infants were identified, 508 (89%) born ≥ 34 weeks' gestation and ≥ 2 kg. More mature infants had higher APGAR scores, shorter duration of mechanical ventilation, and were more likely to receive extracorporeal membrane oxygenation (ECMO). Overall, mortality for the cohort was 29%, with mortality lower in infants born ≥ 34 weeks' gestation and ≥ 2 kg (26 vs. 50%, p < 0.01). Nonsurvivors were more likely to receive treatment with high-frequency oscillatory ventilation (HFOV), vasopressors, pulmonary vasodilators, and ECMO, and to have associated major congenital anomalies than survivors. In hospital morbidity and complications were relatively uncommon among survivors. Conclusion Infants with CDH have a high risk of morbidity and mortality, and for preterm infants with CDH those risks are amplified. Patterns of respiratory and circulatory support appeared to be different for survivors. In addition to established data registries, this consortium of regional neonatal intensive care units provides a new collaborative effort to describe short-term outcomes for infants referred with CDH.
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PMID: 25825963 [PubMed - as supplied by publisher]