Link: https://www.ncbi.nlm.nih.gov/pubmed/30346634

Prenat Diagn. 2018 Oct 22. doi: 10.1002/pd.5376. [Epub ahead of print]
Congenital diaphragmatic hernia: Impact of contemporary management strategies on perinatal outcomes.
Lee HS1, Dickinson JE2, Tan J3, Nembhard W3,4, Bower C5.
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Abstract
OBJECTIVE:
To review temporal changes in perinatal management and one-year survival outcomes of cases of congenital diaphragmatic hernia (CDH) from 1996-2015 in Western Australia (WA).

METHOD:
Retrospective study of all cases of CDH in WA from 1996 to 2015, identified from 5 independent databases within the WA health network. Detailed information pertaining to pregnancy and survival outcomes were obtained from review of maternal and infant medical records.

RESULTS:
There were 215 cases of CDH with 164 diagnosed prenatally. Between 1996-2010, a decline in livebirth rates for CDH-affected pregnancies was observed, reaching a nadir of 5.3 per 10,000 births, before increasing to a peak of 9.73 per 10,000 births in 2011-2015. A corresponding decline was seen in the number of pregnancies terminated in the same period, from 8.3 to 4.6 per 10,000 births (P = .14) and an increase in survival of livebirths, from 38.9% to 81.3% (P = 0.01).

CONCLUSION:
The improved overall survival rate in infants with CDH over the last 20 years may have resulted in an increased tendency for women to continue their pregnancy with a concomitant decline in termination rates. Information from this study will help in the counselling of women following prenatal detection of CDH.

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PMID: 30346634 DOI: 10.1002/pd.5376