Link: https://www.ncbi.nlm.nih.gov/pubmed/30618058

Prenat Diagn. 2019 Jan 7. doi: 10.1002/pd.5413. [Epub ahead of print]
Reproducibility of fetal lung-to-head ratio in left diaphragmatic hernia across the North American Fetal Therapy Network (NAFTNet).
Abbasi N1, Ryan G1, Johnson A2, Sanz Cortes M3, Sangi-Haghpeykar H4, Ye XY5, Shah PS5,6, Benachi A7,8, Saada J7,8, Ruano R9; NAFTNet.
Author information
Abstract
OBJECTIVE:
To determine the antenatal sonographic lung area measurement method in left congenital diaphragmatic hernia (CDH) with the highest inter-rater agreement amongst North American Fetal Therapy Network (NAFTNet) centers within and outside the fetoscopic tracheal occlusion (FETO) consortium and in comparison to a European "expert" reviewer (ER).

METHODS:
Nineteen members from 9 FETO consortium centers and 29 reviewers from 17 non-FETO centers reviewed ultrasound clips of the chest from 13 fetuses with isolated left CDH and were asked to select a static plane for lung area measurement using antero-posterior (AP), longest and trace methods. Inter-rater agreement in lung area measurements was determined using intra-class correlation coefficient (ICC). Bland-Altman analysis was used to evaluate mean difference (bias) between NAFTNet reviewers and ER.

RESULTS:
Among FETO centers, agreement was highest using trace (ICC 0.94; 95% CI 0.83, 0.9, followed by longest (ICC 0.89; 95% CI 0.75, 0.97) and lowest for A-P (ICC 0.83; 95% CI 0.67, 0.94). Similar trends were noted in non-FETO centers. When compared to ER, bias was lowest for trace: 14 ± 38 mm2 and 19 ± 36 mm2 for FETO and non-FETO centers respectively.

CONCLUSION:
Trace method demonstrated the highest inter-rater agreement and lowest bias across NAFTNet.

This article is protected by copyright. All rights reserved.

PMID: 30618058 DOI: 10.1002/pd.5413