Link: http://www.ncbi.nlm.nih.gov/pubmed/26766165

Pediatr Int. 2016 Jan 14. doi: 10.1111/ped.12922. [Epub ahead of print]
Musculoskeletal abnormalities in congenital diaphragmatic hernia survivors: Patterns and risk factors: report of a Japanese multicenter follow-up survey.
Takayasu H1, Masumoto K1, Goishi K1, Hayakawa M1, Tazuke Y1, Yokoi A1, Terui K1, Okuyama H1, Usui N1, Nagata K1, Taguchi T1; Japanese Congenital Diaphragmatic Hernia Study Group.
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Abstract
AIM:
To investigate the natural history and associated predictors of musculoskeletal deformities in congenital diaphragmatic hernia (CDH) survivors.
METHODS:
A multicenter retrospective survey was conducted among CDH patients between January 2006 and December 2010 in Japan, and a follow-up survey was performed between September 2013 and October 2013. One hundred and eighty-two (79.8%) of the 228 patients were alive. An orthopedic survey of 159 survivors without severe coexisting congenital anomalies was subsequently carried out, and the rates of PE (pectus excavatum), scoliosis and chest asymmetry were evaluated.
RESULTS:
Scoliosis, PE and chest asymmetry were found in 20 (12.6%), 19 (11.9%) and 12 (7.5%) patients, respectively. In total, 44 patients (27.7%) developed orthopedic abnormalities. A reduction in the oxygenation index within 24 hours after birth (p=0.044), large diaphragmatic defects (p=0.047) and patch repair (p=0.014) were predictive for scoliosis. In addition, the Apgar scores at 5 minutes were significantly lower in the patients who developed PE (p=0.034), and stomach herniation (p=0.004), liver herniation (p=0.013) at the prenatal diagnosis and large diaphragmatic defects (p=0.036) were predictive of chest asymmetry.
CONCLUSIONS:
Approximately one-quarter of the survivors developed musculoskeletal abnormalities in our survey of CDH patients. These data suggest that each musculoskeletal abnormality has its own specific predictors. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
congenital diaphragmatic hernia; musculoskeletal abnormality
PMID: 26766165 [PubMed - as supplied by publisher]
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