J Pediatr Surg. 2019 Jan 31. pii: S0022-3468(19)30058-2. doi: 10.1016/j.jpedsurg.2019.01.021. [Epub ahead of print]
Prenatal prediction of survival in congenital diaphragmatic hernia: An audit of postnatal outcomes.
Petroze RT1, Caminsky NG1, Trebichavsky J2, Bouchard S2, Le-Nguyen A3, Laberge JM1, Emil S1, Puligandla PS4.
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Effective antenatal counseling in congenital diaphragmatic hernia (CDH) relies on proper measurement of prognostic indices. This quality initiative audited the accuracy of prenatal imaging with postnatal outcomes at two tertiary pediatric referral centers.

Prenatal lung-head ratio (LHR) and total fetal lung volume (TFLV) for CDH patients treated between 2006 and 2017 were retrieved. Study inclusion required at least one LHR or TFLV measurement between 24 and 32 weeks gestational age. Postnatal outcomes [mortality, extracorporeal life support (ECLS) need, patch repair, persistent pulmonary hypertension, oxygen requirement at 28 days] were abstracted from the Canadian Pediatric Surgery Network (CAPSNet) database and local chart review. Univariate and descriptive analyses were conducted.

Eighty-two of 121 eligible CDH patients (68%) were included. Overall mortality, ECLS rates, and patch repair were 33%, 12.5%, and 45%, respectively. Lower LHR values correlated with increased rates of each outcome and persisted despite multiple measurements. Values obtained were higher than those in published schemata. LHR values >45% were most associated with survival, avoidance of ECLS, and primary repair. TFLV values only correlated with mortality and patch repair.

This audit confirms that LHR and TFLV values predict CDH outcomes. However, absolute values obtained require careful interpretation and internal review.


Copyright 2019 Elsevier Inc. All rights reserved.

Congenital diaphragmatic hernia; Fetal MRI; Lung-to-head ratio; Prenatal risk stratification; Prenatal ultrasound; Prognosis

PMID: 30786991 DOI: 10.1016/j.jpedsurg.2019.01.021