Link: https://www.ncbi.nlm.nih.gov/pubmed/30607885

World J Pediatr. 2019 Jan 3. doi: 10.1007/s12519-018-0215-x. [Epub ahead of print]
Management of persistent pulmonary hypertension in newborns with ECMO support: a single center's experience.
Ye LF1, Fan Y1, Shu Q1, Lin R2.
Author information
Abstract
BACKGROUND:
To summarize the experience of management of persistent pulmonary hypertension of the newborn (PPHN) with extracorporeal membrane oxygenation (ECMO) support.

METHODS:
We presented three neonates with PPHN supported by ECMO in our center. Medical records and patient management notes were retrospectively reviewed.

RESULTS:
For two neonates with congenital diaphragmatic hernia (CDH), diaphragm repair surgery was done under ECMO support. One patient was weaned from ECMO after 73 hours, and recovered well at the last follow-up after 1 year. The other patient was weaned from ECMO after 167 hours, and he died from septic shock 21 days after decannulation. For the neonate with idiopathic PPHN, ECMO was withdrawn successfully.

CONCLUSIONS:
ECMO is an effective rescue means for refractory PPHN. Appropriate intervention timing, accurate coagulation, and volume management are important.

KEYWORDS:
Extracorporeal membrane oxygenation; Persistent pulmonary hypertension of the newborn

PMID: 30607885 DOI: 10.1007/s12519-018-0215-x