Link: http://www.ncbi.nlm.nih.gov/pubmed/25783376

J Pediatr Surg. 2015 Feb 20. pii: S0022-3468(15)00108-6. doi: 10.1016/j.jpedsurg.2015.02.028. [Epub ahead of print]
Persistent hypercarbia after resuscitation is associated with increased mortality in congenital diaphragmatic hernia patients.
Abbas PI1, Cass DL2, Olutoye OO2, Zamora IJ1, Akinkuotu AC1, Sheikh F1, Welty SE3, Lee TC4.
Author information
Abstract
BACKGROUND:
Within congenital diaphragmatic hernia (CDH) care, there have been attempts to identify clinical parameters associated with patient survival, including markers of postnatal pulmonary gas exchange. This study aimed to identify whether postnatal pulmonary gas exchange parameters correlated with CDH patient survival.

METHODS:
A retrospective review was performed of isolated CDH neonates treated at a single institution from 1/2007 to 12/2013. Patient demographics, prenatal imaging, and postnatal clinical parameters, including arterial blood gas values within the first 24hours of life, were collected.

RESULTS:
Seventy-four patients with isolated CDH were identified. Fifty-seven had fetal MRI. Overall, 30-day patient survival was 85%. Sixteen infants (22%) required ECMO within 24hours. Mean initial PaCO2 in nonsurvivors was higher, and infants who remained hypercarbic postresuscitation (72±19mmHg) had a worse prognosis than those who resuscitated to a normal PaCO2 (39±1.6mmHg) (p<0.001). Prenatal fetal lung volumes measured by MRI were not strongly correlated with PaCO2 levels.

CONCLUSION:
CDH nonsurvivors are unable to maintain sufficient pulmonary gas exchange during the first 24hours of resuscitation. Furthermore, prenatal fetal lung volumes are weakly correlated with actual pulmonary gas exchange. These data may be useful for patient counseling during the resuscitative phase of CDH care.

Copyright © 2015. Published by Elsevier Inc.

KEYWORDS:
Arterial blood gas; Congenital diaphragmatic hernia; Hypercarbia; Mortality; Prenatal imaging
PMID: 25783376 [PubMed - as supplied by publisher]