Link: http://www.ncbi.nlm.nih.gov/pubmed/27228382

Pediatr Pulmonol. 2016 May 26. doi: 10.1002/ppul.23481. [Epub ahead of print]
Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors.
Bojanić K1, Grizelj R2, Dilber D3, Å*arić D3, Vuković J2, Pianosi PT4, Driscoll DJ5, Weingarten TN6, PritiÅ¡anac E2, Schroeder DR7, Sprung J6.
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Abstract

BACKGROUND:
Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age-matched controls and whether CPET results among CDH survivors differ according to self-reported daily activity.

METHODS:
In one medical center in Croatia, CDH survivors-patients with surgically corrected CDH who were alive at age 5 years-were invited to participate in spirometry and CPET. Values were compared with those of controls matched 2:1 by age and sex for each CDH survivor aged 7 years or older.

RESULTS:
Among 27 CDH survivors aged 5-20 years, 13 (48%) had continued symptoms or spirometric evidence of pulmonary disease. Compared with controls (n = 44), survivors (n = 22) had lower peak oxygen consumption (V˙O2 mean [SD], 35.7 [6.9] vs. 45.3 [8.2] ml/kg per min; P < 0.001). At peak exercise, V˙O2/heart rate (P < 0.001), tidal volume (P = 0.005), and minute ventilation (P < 0.001) were lower in survivors, but the maximal respiratory rate was not different (P = 0.72). Among survivors, mean (SD) V˙O2peak (ml/kg per min) differed by self-reported activity level: athletic, 40.3 (5.0); normal, 35.8 (6.5); and sedentary, 32.1 (6. (by ANOVA, P = 0.10 across three groups and P = 0.04 athletic vs. sedentary).

CONCLUSION:
More than half of CDH survivors continue to have chronic pulmonary disease. CDH survivors had lower aerobic exercise capacity than controls. Self-reporting information on daily activities may identify CDH patients with low V˙O2max who may benefit from physical training. Pediatr Pulmonol.. © 2016 Wiley Periodicals, Inc.

PMID: 27228382 [PubMed - as supplied by publisher]