Link: https://www.ncbi.nlm.nih.gov/pubmed/31123056

Arch Dis Child Fetal Neonatal Ed. 2019 May 23. pii: fetalneonatal-2019-316906. doi: 10.1136/archdischild-2019-316906. [Epub ahead of print]
Physiologically based cord clamping improves cardiopulmonary haemodynamics in lambs with a diaphragmatic hernia.
Kashyap AJ1,2, Hodges RJ1,3, Thio M4,5, Rodgers KA1,2, Amberg BJ1,2, McGillick EV1,2, Hooper SB2,6, Crossley KJ1,2, DeKoninck PLJ6,7.
Author information
Abstract
OBJECTIVE:
Lung hypoplasia associated with congenital diaphragmatic hernia (CDH) results in respiratory insufficiency and pulmonary hypertension after birth. We have investigated whether aerating the lung before removing placental support (physiologically based cord clamping (PBCC)), improves the cardiopulmonary transition in lambs with a CDH.

METHODS:
At ≈138 days of gestational age, 17 lambs with surgically induced left-sided diaphragmatic hernia (≈d80) were delivered via caesarean section. The umbilical cord was clamped either immediately prior to ventilation onset (immediate cord clamping (ICC); n=6) or after achieving a target tidal volume of 4 mL/kg, with a maximum delay of 10 min (PBCC; n=11). Lambs were ventilated for 120 min and physiological changes recorded.

RESULTS:
Pulmonary blood flow (PBF) increased following ventilation onset in both groups, but was 19-fold greater in PBCC compared with ICC lambs at cord clamping (19±6.3 vs 1.0±0.5 mL/min/kg, p<0.001). Cerebral tissue oxygenation was higher in PBCC than ICC lambs during the first 10 min after cord clamping (59%±4% vs 30%±5%, p<0.001). PBF was threefold higher (23±4 vs 8±2 mL/min/kg, p=0.01) and pulmonary vascular resistance (PVR) was threefold lower (0.6±0.1 vs 2.2±0.6 mm Hg/(mL/min), p<0.001) in PBCC lambs compared with ICC lambs at 120 min after ventilation onset.

CONCLUSIONS:
Compared with ICC, PBCC prevented the severe asphyxia immediately after birth and resulted in a higher PBF due to a lower PVR, which persisted for at least 120 min after birth in CDH lambs.

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

KEYWORDS:
congenital diaphragmatic hernia; neonatal transition; perinatal care; pulmonary hypertension

PMID: 31123056 DOI: 10.1136/archdischild-2019-316906