Link: https://www.ncbi.nlm.nih.gov/pubmed/29383650

J Autism Dev Disord. 2018 Jan 30. doi: 10.1007/s10803-018-3472-6. [Epub ahead of print]
Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.
Danzer E1, Hoffman C2, D'Agostino JA2, Miller JS3, Waqar LN2, Gerdes M2, Bernbaum JC2, Rosenthal H2, Rintoul NE2, Herkert LM2, Peranteau WH2, Flake AW2, Adzick NS2, Hedrick HL2.
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Abstract
To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.