I'm going to go out on a limb here, but here goes...

Do we know if there could be 1 or more defective gene sub-component like a particular protein or RNA that could be present in most, if not all, of the chromosomes that be responsible for CDH showing up in so many different chromosomal locations?

Is it possible that CDH could wind up being another connective tissue disorder? After all defects in connective tissues can do some strange things... Maybe it could account for some the variations like eventrations & Late Presentation CDH (LP-CDH)???

*** Full Disclosure: Our CDH family is one of a 1/2 dozen families with Marfan syndrome, and there are several on the list with Ehlers–Danlos & Beals. ***

Shelly Moore